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Visualizing the Brain Thinking
Exploring the Brain Mysteries

Cellular and Sub-cellular Resolution
High-resolution Imaging

Free-behaving Animal Stable &
Real-time Imaging

Three-dimensional Imaging
at Different Focal Planes

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Technology Background

Two-photon fluorescence microscope is a new technology which combines the basic principles of confocal microscope and two-photon excitation. FIRM-TPM is a wearable two-photon microscope for monitoring neural activity in freely behaving animals.

FIRM-TPM is a miniaturized microscope without sacrificing imaging resolution, speed, fluorescence signal and imaging stability. It is the first microscope being able to capture dynamic image from neural or single spines in freely moving mice worldwide. This innovation was awarded "Method of The Year 2018" with other free-moving animals imaging methods by Nature Methods, and it won such a title”a revolutionary new tool for neuroscience research."

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  • Copyright © 2017 Beijing Transcend Vivoscope Co., LTD
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Product Display

  • Miniature Two-photon Microscope

    The fast high-resolution miniature two-photon microscope (FIRM-TPM) acquires the first batch of cellular-resolution imaging data of single neurons and spines in freely behaving mice all over the world.

    This head-mounted microscope can capture calcium dynamics of neurons and spines in awake mouse, effectively transmit 920-nm femtosecond laser pulses to obtain GFP or GCaMP signal, and track the same nueronal population in the same brain region accross multiple days or weeks. Particularly, it can not only be integrated with a Z-scanning module for three-dimensional imaging and multi-plane imaging in the study of neural circuitry, but can also be combined with optogenetics to precisely manipulate neural activity. FIRM-TPM has been widely used in in vivo imaging, especially in the field of neuroscience, and its application has been well extended to the fileds like skin imaging, stem cell study, diagnosis and treatment of diseases, etc.

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  • Optoelectronic Products

    Based on our expertise in the R&D and production of miniature two-photon microscope, we offer advanced optoelectrinic product series, which includes 1030 femtosecond fiber laser, 1560 femtosencond fiber laser, ect.


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  • Microscope Relevant Parts

    We offer a product line of miniature microscope relevant parts for in vivo imaging that uses the wearable microscope.


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  • Miniature Two-photon Microscope
  • Optoelectronic Products
  • Microscope Relevant Parts
  • Tel:+86 10 6254 6960 E-mail:info@tvscope.cn
  • Copyright © 2017 Beijing Transcend Vivoscope Co., LTD
  • WeChat
  • +86 400 998 9826

Contact Us

  • Beijing Transcend Vivoscope Bio-Technology Co., LTD

    Address:Room 508, 5th Floor, Building 1, No. 13, Cuihu Nanhuan Road, Haidian District, Beijing, PRC

    Tel:+86 10 6254 6960

    Postcode:100094

  • Nanjing Transcend Vivoscope Bio-Technology Co., LTD

    Address:B2-1,Building 16,Treehouse,73 Tanmi Road, Jiang Bei Xin Qu District, Nanjing, Jiangsu, P. R. CHINA

    Tel:+86 25 5889 5768

    Postcode:211800

  • For product inquiry, please contact us with the following information:

    Tel:+86 400 998 9826

    E-mail:info@tvscope.cn

  • For after-sales services, please use the information below to reach us:

    Tel:+86 400 998 9826

    E-mail:service@tvscope.cn

  • Method of the Year 2018

  • China's Top Ten Scientific Advances in 2017

  • China's Top Ten Progress of Optics in 2017

  • China's Top Ten Medical Technology News of the year In 2017

  • Tel:+86 10 6254 6960 E-mail:info@tvscope.cn
  • Copyright © 2017 Beijing Transcend Vivoscope Co., LTD
  • WeChat
  • +86 400 998 9826